GEN-3000 Lecture Notes - Lecture 7: Homologous Chromosome, Chromosome Segregation, Mendelian Inheritance
21 Feb 2017
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Chapter 7 - linkage, recombination, and gene mapping. Morgan (morgan suggested that genes on same chromosome segregation together - also, those closely linked were rarely subject to recombination) 1911 sturtevant generated first map of chromosome based on recombination frequency. Each diploid individual possesses two alleles that separated in meiosis, one allel to each gamete (each allele is at the same position on a homologous chromosome) Two alleles separate independently of alleles at other loci. Chromosome theory of inheritance - sutton, genes are found on chromosomes. F1 generation not recombinant genes (or parental gametes) Can also have new combinations of alleles. Those that are close together on same chromosome - travel together during meiosis, do. We did not see the 9:3:3:1 ratio that mendel got. Not allowed to sort independently - so now we have an over representation of the. Means they are physically located on the same chromosomes parentals. Leads to switching of genes from one homologous chromosome to another.
