BIOL-242 Lecture Notes - Lecture 53: Oxidative Deamination, Keto Acid, Citric Acid Cycle
16 Jun 2020
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Document Summary
Proteins deteriorate, so continually broken down and replaced. Amino acids recycled new proteins or different compound protein not stored in body. When dietary protein in excess, amino acids. First deaminated (nh2 removed); then converted into. Events include transamination, oxidative deamination , and keto acid modification. Amine alpha-ketoglutaric acid glutamic acid; amino acid keto acid. Oxidative deamination in liver rids body of toxic ammonia. Nh3 removed from glutamic acid alpha-ketoglutaric acid; removed nh3. Urea released to blood; excreted in urine. Keto acids from transamination altered to metabolites to krebs cycle. Pyruvic acid, acetyl coa, alpha-ketoglutaric acid, oxaloacetic acid. Those pyruvic acid can become glucose for gluconeogenesis. Form all proteins; bulk of functional molecules. Synthesize 225 450 kg protein during lifetime. Organic molecules (except dna) continuously broken down and rebuilt. Amount and direction of conversion directed by liver, adipose tissue, skeletal muscle. Body"s total supply of free amino acids. Proteins lost in urine, hair, skin cells.
