KINE 1020 Lecture Notes - Lecture 8: Reactive Oxygen Species, Oxidative Phosphorylation, Pyruvic Acid

• School: York University
• Department: Kinesiology & Health Science
• Course: KINE 1020
• Professor: Michael Riddell

Document Summary

Ca(cid:374)(cid:859)t (cid:271)uild up force, action potential: sarcolemma: fatigue is at the site associated with a change in membrane potential. Sodium (na+) and potassium (k+) imbalance: na+/k+ atpase becomes i(cid:374)hi(cid:271)ited, (cid:373)e(cid:373)(cid:271)ra(cid:374)e (cid:373)a(cid:455) (cid:271)e(cid:272)o(cid:373)e (cid:858)leak(cid:455)(cid:859) to io(cid:374)s. Does this counteract action potentials: t-tubule: fatigue is associated with a drop-in strength or size (amplitude) of the action potential. You (cid:272)a(cid:374)(cid:859)t rela(cid:454) the (cid:373)us(cid:272)le for the (cid:374)e(cid:454)t (cid:272)o(cid:374)tra(cid:272)tio(cid:374) (cid:272)a(cid:374) (cid:271)e (cid:272)ause of cramps: generally referred to as calcium overload. In fatigue, there (cid:272)a(cid:374) (cid:271)e a(cid:272)tio(cid:374) pote(cid:374)tials (cid:271)ut if the (cid:272)al(cid:272)iu(cid:373) (cid:272)ha(cid:374)(cid:374)el (cid:272)a(cid:374)(cid:859)t ope(cid:374) the(cid:374) (cid:272)al(cid:272)iu(cid:373) (cid:272)a(cid:374)(cid:859)t (cid:271)e released: (cid:1006) reaso(cid:374)s: (cid:1005). Ca(cid:374)(cid:859)t release it, a(cid:374)d (cid:272)a(cid:374)(cid:859)t (cid:271)ri(cid:374)g it (cid:271)a(cid:272)k up: actin myosin interaction contractile force generation, increasing inorganic phosphate in cytoplasmic space. Which delays detachment phase of a-m cross bridges. Lack of atp, adp is up cause of cramps, keeping the adp to myosin: increasing hydrogen ions levels will decrease the ph. Heavy exercise from 7. 2 to 6. 8 (more acidity)