BIOL 1000 Lecture 5: Chapeter 5 Notes Biology

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24 Apr 2020
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Individuals with alkaptonuria have a defective alkapton-metabolizing enzyme: unaffected individuals have an enzyme that breaks down alkapton, garrod further hypothesized that enzymes are under control of the hereditary material. And thus an error in the hereditary materaill resulted in an error in an enzyme. George beadle and edward tatum: thirty years later after garrod first hypothesized a relationship between genes and enzymes, In other experiment, they placed colonies of mutant strain in vials, each containing minimal medium plus one additional nutrients: beadle and tatum observed that one mutant strain only grew on minimal medium containing the amino acid arginine. Other strains could not grow in the absence of citrulline or ornithine; therefore defective enzyme a or b. The central dogma: dna is too valuable to the normal functioning of the cell to be allowed to exit the nucleus. Rna into specific sequences of amino acid, which are used to build proteins.

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