BIOL 1000 Lecture Notes - Lecture 18: Electron Transport Chain, Electrochemical Gradient, Citric Acid Cycle
BIO 1000: Cellular respiration
Glycolysis – split sugar into 2 three carbon molecules. Net generation of ATP
Pyruvate oxidation – trasitio etee glyolysis ad ker’s yle. Pyruate oerted ito
acetyl-CoA (net of 2). 2 NADH produced and 2 CO2 released.
Kre’s Cyle – complete oxidation of glucose. Generate a bit of ATP and electron carriers
Electron Transport Chain – transferring protons (H+) from the matrix to the intermembrane
space creating the proton concentration gradient.
Chemiosmosis – bulk of ATP generation. Harnessing energy present in proton gradient to drive
chemical reactions
In cellular respiration we make a total of 10 NADH and 2 FADH2
for eah NADH e get ATP’S
for each FADH2 e get ATP’S
So 10 x 3 = 30 ATP
2 x 2 = 4 ATP
Add that up and you get 34 ATP from chemiosmosis
So the net ATP production is then 34 ATP from oxidative phosphorylation
2 ATP from glycolysis
ATP fro the to turs of the Kre’s yle
which gives us a grand total of 38 ATP
you must invest 2 ATP
• Per turn of krebs
o ATP – 2
o FADH2 – 2
o NADH – 6
Electron transport chain – inner membrane
o Proton gradient
o NO ATP MADE IN ETC
• Complex 1 = dehydrogenase – oxides NADH (moving of hydrogen)
• Complex 2 = dehydrogenase
• Comples 1 & 4 = allow movement into intermembrane space
• Ubiqinone – shuttle moving from one complex to the next
• Energy releases as you move from complex to complex
• Electron flow goes from high to low electron energy
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Document Summary
Glycolysis split sugar into 2 three carbon molecules. Pyruvate oxidation tra(cid:374)sitio(cid:374) (cid:271)et(cid:449)ee(cid:374) gly(cid:272)olysis a(cid:374)d ker(cid:271)"s (cid:272)y(cid:272)le. Pyru(cid:448)ate (cid:272)o(cid:374)(cid:448)erted i(cid:374)to (cid:1005) acetyl-coa (net of 2). Generate a bit of atp and electron carriers. Electron transport chain transferring protons (h+) from the matrix to the intermembrane space creating the proton concentration gradient. Harnessing energy present in proton gradient to drive chemical reactions. In cellular respiration we make a total of 10 nadh and 2 fadh2 for ea(cid:272)h nadh (cid:449)e get (cid:1007) atp"s for each fadh2 (cid:449)e get (cid:1006) atp"s. Add that up and you get 34 atp from chemiosmosis. So the net atp production is then 34 atp from oxidative phosphorylation.