Pharmacology 3620 Lecture Notes - Lecture 23: Monoamine Oxidase B, Levetiracetam, Protein Kinase
29 Dec 2016
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Site of action for many drugs (e. g. blocking nmda receptors, neuroleptics blocking da receptors, changing neurochemistry of 5ht synapse w/ ssris, etc). Drugs of abuse also act on synapse (e. g. amphetamines) Be comfortable w/ the way a synapse works understand pre vs post synaptic activity. Pre-synaptic activity vs post-synaptic activity may vary for drugs. Understand what is going on in these processes. Know basic pharmacology of glutamate & gaba receptors. Anti-cholinesterase activity increases ach uptake by decreasing breakdown and increasing neurosynthesis of ne/dopamine, etc. Neuropeptides are often for antagonism (only mentioned a couple times) The concept of ion channel as a target is important. Many examples of ach being the target molecule for pharmacotherapy b/c of its activity on ion channels. Cholinesterase inhibition increases the activity of these receptors/ion channels: e. g. Gaba receptors in general anesthetics: e. g. antagonize ion channel or blocking the pore (e. g. pcp, lidocaine for local anesthetics)
