Pathology 3500 Lecture Notes - Lecture 9: Hypotension, Leukocytosis, Tuberculosis
21 Mar 2018
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Document Summary
Malaria: not a virus or bacteria it is a paracitic organism, affects 40% of the worlds population. Intracellular parasite: protozoa (single cell organism, life cycle. Sporozoites (mosquito salviary gland) --> blood stream of human --> invade liver cells. Lysis of cells: alter the cells, makes rbcs sticky-->clump, stick to vessel wall -->narrow vessel lumen and decrease blood flow, dissemination, by infected rbcs, transmission. How do we prevent - host"s defenses to neutralize the organism. Host factors -- prevention is the best medicine. Host: personal hygiene and good skin care. Host: epithelial and epidermal barriers (anything exposed to the outside world/environment, skin, gastrointestinal system, respiratory system, urogenital tract, all of these have defenses that are non specific. Skin: defences, continued skin turnover, low ph (<5. 5, presence of fatty acids (prevents proliferation, compromised by, breakage by trauma, burns, injuries (ex. Bite, fungal prick, wounds, needles: excess moisture changes ph and presence of fatty acids, only few microorganisms can traverse unbroken skin.
