PSL301H1 Lecture Notes - Lecture 3: Antigen, B Cell, Thymus
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Psl301 lec 3: acquired immunity: specificity: respond to specific pathogens. B/t cells recognize specific shapes on antigens: versatility: able to response to many types of pathogens. Different b/t cells have diff receptors: memory: remembers previous antigens. B/t cells can be long lasting: tolerance: able to respond only to foreign substances. B/t cells that recognize self are deleted. Antibodies on surface that binds to extracellular antigens. Encounter antigens in secondary lymphoid tissues initiate immune response. T cell receptor binds to antigens presenting cells (e. g. macrophages, tissue cells, etc ) Binds to cells that exhibit mhc on the surface. One type of cell is dividing clones of cells with same receptor some differentiate into effector cells or memory cells. Faster response because of blood after a week. When no more infection, # of antibodies decrease memory. Antibody response rise high immediately how vaccine works. Undergo positive and negative selection in bone marrow. Cells that react to self-proteins are deleted.
