PSL301H1 Lecture Notes - Lecture 3: Fragment Antigen-Binding, Immunoglobulin Light Chain, Thymus
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PSL301H1 Full Course Notes
Verified Note
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Document Summary
What is the structure of an antibody: specificity, versatility, memory, tolerance. Some activated b and t cells are long lasting. B and t cell receptors that recognize self-antigens are deleted or not activated. Antigens on the surface of cells in the context of mhc. Secondary lymphoid tissues (not bone marrow or thymus) Clonal expansion resulting in short lived effector cells and long-lived memory cells. Primary immune response takes longer and has a lower magnitude than secondary immune response. B cells in the bone marrow and t cells in the thymus via positive and negative selection. 2 heavy and 2 light chains with the heavy chain being a part of the fc regions and fab regions while light chains are only in fab regions. Fight parasite and trigger histamine degranulation from eosinophils. Active involves being exposed to antigens and passive involves being exposed to antibodies.
