PSL301H1 Lecture 27: L27 Acid-Base Balance
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PSL301H1 Full Course Notes
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Document Summary
A 45-year-old man with end-stage kidney disease undergoes dialysis three times per week. On the weekend, he had the stomach flu and experienced diarrhea. On monday morning, he felt unwell, so he went back to bed and missed dialysis. When seen in the emergency room, the following data was obtained: End stage kidney disease damage to kidneys so he has no kidney function (don"t need to reabsorb bicarb, because they don"t filter it, but they can"t have ammoniagenesis) Gi fluid is rich in bicarbonate (i. e. , diarrhea, etc. : diarrhea is associated with loss of bicarbonate extremely sensitive to this. Without kidney function, need at least one form of dialysis treatment three times a week. Dramatic biochemistry in vascular compartment markedly acidemic, and decrease in bicarbonate levels. Partial pressure of co2 in blood is an indirect measure of minute ventilation relative to metabolic rate. Failure to hyperventilate in response to metabolic acidosis makes the ph lower.
