BCH210H1 Lecture Notes - Lecture 9: Aspartic Acid, Valine, Alanine

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Reinhart Reithmeier

Document Summary

Cannot precisely predict the helical, sheet, turns, and random regions in. 3d space: unless x-ray, or nuclear magnetic resonance (nmr) Can provide insight into protein function & interactions. Ramachandran plots only tell us % of each secondary structures in proteins. From known protein structures find patterns. General trends: so not exactly super comprehensive. Residues are categorized as: -helix, -sheet, -turn, or disordered regions: from ramachandran plots. Consecutive sequences of 4+ helix-formers designated as turns: 4 helix-formers 1 turn, 7 helix-formers 2 turns. Consecutive 3+ -sheet formers designated as -sheets. Residues not falling into either category disordered. Residues in -turns designated after structure analysis: need at least 4 aa"s to make a turn. Average frequency: f falpha = 0. 38 ( -helix) fbeta = 0. 20 ( -sheet) fturns = 0. 32 ( -turns) Paa: (frequency of that aa in conformation) / (frequency of conformation)