BIO230H1 Lecture Notes - Lecture 2: Cadherin, Metastasis, Nitroglycerin
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BIO230H1 Full Course Notes
Verified Note
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Document Summary
Biosynthetic-secretory pathway: constitutive secretory pathway, regulated secretory pathway. Invagination: fission, sorting: recycling, transcytosis, degradation, example: uptake of cholesterol. Invagination clathrin, copi, copii: fusion snares, fission dynamin, budding to form multivesicular bodies escrt complex. Directing trafficking: snares, signaling lipids (pips) Different positions on the inositol head are phosphorylated. Each pip binds to a specific protein. Specific pips are found at specific sites in the trafficking network and their protein partners are recruited to these sites: small gtpases. Localized in the cell and bind/activate downstream effectors. Recruited by rabgefs exposes lipid anchor, which is inserted into pm bind downstream effectors interacts with pips and snares. Rab7: late endosomes: signal sequences on cargo, membrane composition. Microtubules: polarized heterodimers, and -tubulins that hydrolyze gtp, 13 protofilaments form a microtubule. Tubulin ring complexes associate with mtoc (centrosomes) and nucleate microtubules at the (-) end: dynamic instability. Rescue: gain of gtp cap: microtubule networks can form a coordinate system on their own.
