BIO230H1 Lecture Notes - Lecture 22: Anaphase-Promoting Complex, Cdk Inhibitor, Cyclin E
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BIO230H1 Full Course Notes
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Document Summary
The cell cycle is the duplication of cellular contents and division of these contents by two. A critical aspect of cell division is the fidelity with which the . Act as the traffic lights that control the cell cycle. Targeted degradation eg. anaphase promoting complex (apc) targets. M-cyclin to the proteasome, allowing the completion of mitosis. Clamp distorts the active site and blocks the atp binding site. Wee1 kinase phosphorylates a different site, inactivating it. Cdc25 phosphatase removes this phosphate, activating it. Rb blocks g1 progression and s phase by inhibiting cyclin synthesis. E2f (a tf) is involved in s-phase gene transcription. G1/s-cyclin (cyclin e) and s-cyclin (cyclin a) Active g1-cdk will phosphorylate rb, inactivating it. Mitogen signalling induces myc transcription via a ras-map kinase signaling cascade. Myc increases cyclin synthesis & cki degradation by regulating transcription. P53 stops the cell cycle in response to dna damage. Apoptosis most common form of programmed cell death.
