BIO230H1 Lecture Notes - Lecture 12: E2F, Histidine, Basal Lamina

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31 Jan 2018
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BIO230H1 Full Course Notes
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Green at the key proteins, red a eless commonly changed proteins. Cells adhere to eachother thru cadherin proteins, and is metastases they break away. E2f is a o(cid:374)(cid:272)oge(cid:374)e, a(cid:374)d r(cid:271) stops (cid:272)ell proliferatio(cid:374), so it"s a tu(cid:373)or suppressor. Oncogenes and tumor supppressors can function in the same pathway. The one cell that can survive and divide is the clonal origin of cancer, they are all clones of that one cell. Near 30 doublings, its grown for a long time before we can detect it on an x-ray. 30 is when we can feel the tumor. 40 doublings causes the death of the patient. Early detection is crucial to save the patient. A tumor is not necessarily the same as a cancer, not all tumors are cancers, not all cancers are tumors. Benign tumors are not cancers, malignant tumors are cancerous. In malignant, we have broken the basal lamina and the (cid:272)ell are goi(cid:374)g (cid:449)here they are(cid:374)"t supposed to go.

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