BIO230H1 Lecture Notes - Lecture 24: S Phase, Basal Lamina, Cytochrome P450
31 Jan 2018
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Based on current incidence rates, 40-45% of canadians will develop cancer during their lifetimes. On the basis of current mortality rates, approximately 1 out of every 4 canadians will die from cancer. : www. cancer. ca/statistics. To deal with cancer, we have to understand what leads to cancer at the level of cells and molecules: this is where drugs can target the activity of molecules to counteract the progression and growth of the cancer. Molecular machinery and pathways linked to cancer: cell adhesion molecules, actin cytoskeleton involved in migration of cancer cells, major component of signaling pathways involving control of cell numbers through cell proliferation and cell death. If mutations aren"t fixed, proteins like p53 will continue their activity and kill off those dangerous cells through apoptosis. Cancer develops from one of these cells gaining a mutation that allows it to survive and divide, forming a tumour.
