BIO230H1 Lecture Notes - Lecture 22: Mitosis, P53, Cdk Inhibitor
31 Jan 2018
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BIO230H1 Full Course Notes
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In class course evaluation on thursday: we want to understand molecular mechanisms of cell biology, developmental biology, all related to disease. The genome is what"s passed on from the fertilized egg to all cells of the body (chromosomes) during divisions: critical for species for high fidelity of cell division. Four main phases of the eukaryotic cell cycle. The cell must check if the process is occurring properly. Different cyclin-cdk checkpoints act at different stages of the cell cycle: one complex with s-cdk, and phosphorylation targets trigger dna replication, one complex with m-cdk, and phosphorylation targets trigger mitosis. The production of the cyclin turns on the cdk, in a specific manner. Cyclins and cdks of vertebrates and budding yeasts. First three monitor nutrient conditions and address whether the cell should replicate its dna or not: m-cdk decides whether or not to enter mitosis. Production of cyclin d, e, and a promote s phase, whereas production of cyclin b promotes m phase.
