BIO230H1 Lecture Notes - Lecture 7: Crispr, Small Interfering Rna, Microrna
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BIO230H1 Full Course Notes
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Document Summary
Bio230 lecture 7 - regulation of the proteome (sept. 28) Examples of how rna molecules processed in eukaryotic cells. Need to be properly processed for translation to occur. Quality control mechanisms to make sure rna processing occurs properly. Quality control mechanisms to make sure aberrant rnas not translated. Dependent on poly-a tail (200 a nucleotides) Once length of poly-a tail reaches certain length = signal for rnamolecule to be degraded. Mrna stability can be regulated by mirnas. Encoded in genome and regulate stability of mrna molecules. Can regulate at least of all protein-making genes. Once they base-pair can regulate stability and translation of those mrna mirna synthesis: Synthesized by rna polymerase ii in nucleus. Rna molecules are single stranded = can adopt secondary structures. Can fold back and base pair with themselves mirna processing: Once microrna produced in nucleus special processing occurs called cropping. 5" cap and poly a tail released to release mirna into cytosol.
