BIO220H1 Lecture Notes - Lecture 20: Rodent, Natural Selection, Flu Season
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BIO220H1 Full Course Notes
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Predicting optimal virulence: both transmission and virulence are a function of replication rate within a host, the benefit of replicating within a host: can transmit. Increasing replication rate = increasing benefit: the more replicating within a host, the more virulence (cost) within a host, optimal replication rate, where benefit minus cost is lowest. Intermediate replication rate = intermediate virulence: how does transmission mode affect optimal virulence, direct contact: cost of virulence is higher (host must be mobile/healthy) - cost line has a steeper slope. Virulence evolution theory relies on within host replication being positively related to both virulence and transmission: a lot of evidence and data. Human malaria infections: expected transmission and virulence both increase with replication, for different age classes - effects differ, lower parasite densities as age increases, positive correlation between within host replication and mortality (effect of virulence)
