BIO130H1 Lecture Notes - Lecture 18: Translocon, Secretion, Cell Membrane
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A stretch of the amino acid sequence of a protein that directs the protein to the correct location in the cell. Each signal sequence specifies a specific destination in the cell. Eg. to the nucleus, mitochondria, er, peroxisomes, etc. Signal sequences are recognized by sorting receptors that take proteins to the destination ( srps for er ) Really highlights the power of the genome dna sequence tells the proteins where to go. Signal peptidases can remove the signal sequences that are found on the n-terminus of proteins. Signal sequences can also be internal stretches of amino acids which remain part of the protein ( internal signal sequence or internal start transfer sequence ) Signal sequences on the amino-terminal (n) end directs the protein to the er. Protein is inserted through the membrane by a translocon protein. Signal sequence is cleaved, left behind in er; secreted protein in the er lumen. Secreted protein moves in transport vesicles via the secretory pathway.
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