BIO130H1 Lecture Notes - Lecture 16: Basal Lamina, Electrochemical Gradient, Cell Membrane
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BIO130H1 Full Course Notes
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Lecture 16: membrane proteins & transport across membranes. How is the na + electrochemical gradient maintained? (since both the na + /glucose symporter and na + /h + antiporter are both bringing na + into the cell) Na + /k + pump (a transport atpase ie. an atp driven pump) Both na + and k + are moved against their electrochemical gradient. Atp bound to the pump & 3 na + bind to an open cytosolic pocket. Pocket closes, preventing na + from escaping. Atp hydrolysis occurs, pump is phosphorylated & the release of adp causes a conformational change to e2. In e2, the binding is exposed on the extracellular side and 3 na + exit. 2 k + bind & the pocket closes, preventing the release of k + Atp binds the pump, returning it to the e1 state and k + is released into the cytosol. Transport proteins & how they regulate critical cellular processes.
