BIO130H1 Lecture Notes - Lecture 19: Tamoxifen, Electron Microscope, Leading Edge
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BIO130H1 Full Course Notes
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The transport of nuclear proteins to the nucleus is gated and occurs through nuclear pore complexes. This is regulated by signals including hormones, calcium etc . Regulates the proteins between the cytosol and the nucleus mrna exported by the nuclear pore complex, arrives in the cytosol picked by the ribosome for translation. When translation is completed, the protein will fold in the cytosol and will shuttle through the npc"s if it has the right signal. Rnp (rna + proteins) help shuttle rna out of the nucleus. Npc"s can allow the diffusion of small molecules. When the protein is not mutated it"s found in the nucleus. When the protein is mutated (and there"s a change in the amino acid) the protein will remain in the cytosol and is prevented from entering the nucleus. Nuclear pore complex determines whether or not it can pass through. Proteins that are involved in transcription need to be moved from cytosol to nucleus.