BIO130H1 Lecture Notes - Lecture 8: Reverse Transcriptase, Dna Replication, Telomerase

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2 Mar 2017
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BIO130H1 Full Course Notes
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The chromosomes can"t be replicated all the way at the end, this results in loss of information sequences which results in hair loss, hair color loss, aging etc . The problem with the ends of the chromosome: The ends of the chromosomes can"t be replicated, and when the primer is removed results in the shortening of the strand shorter and shorter in successive replications. Embryonic cells and germ cells dot want to lose important sequence information. Removal of rna primer shortening of strand: telomeres are added on the ends, they are added to the 3" end of the parental strand. Stem cells need to be able to replicate (bone marrow, skin etc ) rapid replication. Telomerase: adds 3" extensions to the parental strand, it has a built in rna template. 5000 times at the 3" end of the template: using the rna template (which is built in), it is able to create a dna complimentary copy.

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