BIO207H5 Lecture Notes - Lecture 10: Lethal Allele, Null Allele, Chinchilla

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The c-gene system for mammalian coat color: many genes are required to produce and distribute pigment to the hair follicles or skin cells, where they give rise to skin or coat color. The c gene is responsible for coat color in mammals like cats, rabbits and mice, etc. It produces an enzyme active in the production of melanin. There are dozens of alleles of the gene, but four that form an allelic series. Dominance relationships in the allelic series: crosses among different genotypes has revealed the dominance relationship of the alleles. The c allele is dominant over all the others. The cch allele is partially dominant over ch: all the alleles are dominant over the c allele. The molecular basis of the c-gene allelic series. The c allele produces a tyrosinase enzyme that is 100% active, whereas that of the cch allele is less than 20% active.

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