BIO200H5 Lecture Notes - Lecture 5: Irreversible Antagonist, Adenosine Receptor, Urinary Retention
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If you add atropine systemically, the side-effects, these all occur when we do(cid:374)"t ha(cid:448)e a(cid:272)h a(cid:448)aila(cid:271)le: dry mouth, decreases secretion of saliva, blurred vision. Induces the contraction of the radial muscles of the pupil: retention of urine, constipation, atropine is used if you want to reduce saliva during surgery. Irreversible: there are some that bind irreversibly, this forms a covalent bond to the receptor and it is very difficult to be released. Slide 15: caffeine will work on adenosine receptors, adenosine is the natural ligand of adenosine receptor. If they are activators, their function is conformational changes of the receptor that make binding to the naturally occurring ligand, more effective response. If a and b are applied together, they will compete because we have a competitive inhibitor: competitive inhibitor usually has more potency to binding to the receptor that is why they induce the inhibition.
