HSS 2342 Lecture Notes - Lecture 11: Cori Cycle, Blood Sugar, Gluconeogenesis

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Amino acid metabolism in the liver: cahill cycle: similar to cori cycle in that muscle makes ketone from proteins and results in alanine which is recycled in the liver. Fasted state increases gulconeogenesis: uses up all available oxaloacetate (start of tca cycle) for making glucose, so tca is not possible. Metabolism in the fed states: in the liver. Increased protein synthesis: in adipose tissue, Decreased triglyceride degradation: in skeletal muscle. Increased protein synthesis: fatty acids are secondary importance as a fuel for muscle in the well-fed state in which glucose is the primary source of energy. Insulin during feasting (don"t need to memorize target enzymes) Metabolic fuel present in a 70 kg man at the beginning of a feast (after starvation i. Metabolism in fasting and starvation: in the liver, Increased ketone body synthesis: in adipose tissue, Decreased fatty acid uptake: in skeletal muscle, Utilize fatty acids from adipose and ketone bodies from the liver as fuels: in the brain,

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