HSS 2342 Lecture Notes - Lecture 10: Blood Sugar, Nicotinamide Adenine Dinucleotide, Gluconeogenesis

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2342
• Professor: Keir J.Menzies

Document Summary

Amino acids to energy and amino acids to glucose: deamination of amino acids, amino acids-to-energy or to-glucose, several entry points in energy pathway: This is because these amino acids provide all the necessary carbons to generate glucose with reactions that we are not discussing here (not simply going backwards up glycolysis). Glucogenic vs. ketogenic aa: understand concepts: do not memorize speci cs here, ketogenic: yield acetyl coa or acac (acetoacetate: a ketone body) as end products of catabolism. Can make glucose later in the tca cycle but technically the (only) 2 carbons provided for acetyl coa is not enough as we still need oxaloacetate from the tca cycle to make glucose. So they are better suited for making ketones then: glucogenic: are degraded to pyruvate or a member of the tca cycle (succinylcoa, oxaloacetate, a-ketoglutarate, fumarate). In absence of sugars, glucogenic amino acids permit continued oxidation of fatty acids by maintaining tca cycle intermediates (adding oxaloacetate).