BIO 3170 Lecture Notes - Lecture 13: Ryhb, Gene Silencing, Eukaryote
11 Apr 2018
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Document Summary
In bacteria: critical for the response to environmental stresses. In eukaryotes: embryonic development, control of gene expression throughout life. In the human gene: a lot of regulation takes place. Transcripts ranging from 100-300 nucleotides in length. Majority acts as full-length rnas, few are processed to shorter fragments. Have only limited complementarity with their target mrna. High iron: no expression of ryhb rna, target rna is translated. Low iron: expression of ryhb rna, target rna is not translated. Ryhb rna binds to the 5" end in the vicinity of the shine-dalgarno motif - blocks ribosome binding. Proteins involved in iron storage won"t be translated. Preventing the formation of secondary structures - changes mrna structure to affect ribosome binding. Enzymatically processed from a longer primary transcript. Use base pairing interactions to bind to their dna or rna targets. Frequently interact with other components (proteins) to perform their regulatory functions.
