BIO 3153 Lecture Notes - Lecture 7: Ubiquitin Ligase, Wee1, Protein Kinase
29 Aug 2016
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Document Summary
Cells spend most of the time in g0 phase as they may be differentiated, spends little time in mitosis. Some cells divide a certain number of times until they terminally differentiate. The cell cycle: looking at control mechanisms, molecular switches (protein) large control of cell signaling, can tell a cell to enter the cell cycle or progress. Cdks control the cell cycle: cyclin-dependent kinase, activity rises and falls with the cell cycle. Inhibition of cdk: wee1 important in how cells get into m-phase, active cdk gets another phosphate added to it by wee1 temporarily inactivates. Cdk: cdc25 a phosphatase that will remove the phosphate, full active cdk complex can be inhibited by p27, it is an inhibitor of cyclin-cdks, binds with both cyclin and cdk, can also bind the active site. Scf and apc are active during different stages: compare the two graphs.
