BIO 1140 Lecture Notes - Lecture 4: Tubulin, Microtubule, Cytoskeleton

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The inside of the cell is a well-organized scaffold of protein structures that carry out more than just a skeletal function for the cell. Functions include: provides structure and support, intracellular transport, position organelles within a cell, generate force for cell movement, contribute to cell division. Microtubules help lining up the chromosomes and bringing them to the poles of the cell. Microtubules: basic units of microtubules are tubulin dimers (a and b tubulins) Must have an alpha and a beta: gtp binding site location confers polarity to mt: +end" and. Polar and soluble: originate from a central point, the mtoc (microtubule organization center) at the centrosome (near nucleus) (at the - end) Cover about 80% of the interior of the cell. Tubulin heterodimers assemble as a single row (protofilament. Their 3d structure assembly of 13 (1 every 28degrees) explain the tubule shape. Hollow inside: transports nutrients in vesicles, transports organelles, intra and extra cellular transportation.

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