BIO 1140 Lecture Notes - Lecture 6: Creb-Binding Protein, Adenylyl Cyclase, Signal Transduction
20 Mar 2016
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Document Summary
Because it is a fatty acid anchored protein. Many different subunits of proteins that interact with these. Structure of receptors span the membrane 7 times and bind ligand on extracellular portion. When the ligand binds, it forces the 7 transmembrane domains to change conformation: when this happens, it recruits trimeric g proteins. Named this because they are made up of 3 protein subunits. When alpha, beta, gamma is recruited and bind to the receptor of gpcr, it induces alpha subunit to exchange gdp for gtp, separate from beta and gamma and activate amplifier enzyme. Multiple ligands some bind to many different gpcrs: ach can bind 5 different types of gpcrs, adrenaline (4 main receptors) Mediate responses to a diverse range of ligands: ex. Neurotransmitters, hormones, odorants, tastants, and photons of light. Diversity of receptors for given ligand translates to multiple responses. Adenylyl cyclase is a membrane enzyme whose cataylytic enzyme is by gtp (g alpha s)
