BIO 1140 Lecture Notes - Lecture 7: Nuclear Membrane, Chromatin, Cytoskeleton

• School: University of Ottawa
• Department: Biology
• Course: BIO 1140
• Professor: Caroline Petit- Turcotte

Document Summary

Calcium: response to stimuli, muscle contraction, signalling (second messenger, enzymatic cofactor (e. g. coagulation) (gap junctions, bones, closing of stomata, metabolism, calcium is toxic to cells, k(cid:396)e(cid:271)s (cid:272)y(cid:272)le, (cid:449)ithout ca the (cid:272)y(cid:272)le slo(cid:449)s do(cid:449)(cid:374). O it"s (cid:374)eeded fo(cid:396) a(cid:374) effi(cid:272)ie(cid:374)t (cid:272)ell (cid:272)y(cid:272)le. Store it in the cytoplasmic reticulum, store it in the mitochondria (number 1), and regulate it with a pump using calcium pump. Binding proteins, lots of those and they bind (cid:272)al(cid:272)iu(cid:373) it"s (cid:374)o lo(cid:374)ger i(cid:374) io(cid:374)i(cid:272) for(cid:373) so (cid:449)ill (cid:271)e hidde(cid:374). Mitochondria and cell death: concentration gradient: channels/transporters, binding proteins: calsequestrin, calbindin, parvalbumine, compartmentalisation: er, mitochondria channels, transporters, replenish reserves. First why: certain mutations, will be preferable to kill those cells rather than perpetuate that (cid:373)utatio(cid:374) if it"s da(cid:373)agea(cid:271)le to the (cid:272)ell. Cell (cid:374)ot (cid:374)eeded a(cid:374)y(cid:373)o(cid:396)e (cid:894)p(cid:396)u(cid:374)i(cid:374)g used fo(cid:396) (cid:374)eu(cid:396)o(cid:374)s a lot). Whatever condition that was ailing the cell if we kill it prevents that ail from spreading to neighbouring tissues.