BIOL 2420 Lecture Notes - Lecture 5: Vascular Smooth Muscle, Autoregulation, Carbonic Anhydrase
15 Nov 2016
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Document Summary
Vascular smooth muscle in vital organs can self regulation tone in response to map changes. Example - increase map = increased arteriolar stretch. Paracrine agents released into ecf surrounding arterioles in response to metabolic changes. In metabolic changes - low o2 and ph, and more co2 and heat. So the tissue/vessel vasodilates to increase flow to supply more o2 and remove the wastes. Carbonic anhydrase makes co2 and h2o into h and hco3. Increased blood flow to tissues in response to increased activity. Autoregulation and exercise: rapidly contracting skeletal muscle and cardiac muscle leads to: Blocks ca entry into smooth muscle cells of: Arterioles - increases blood flow to tissues. Precapillary sphincters - increased the number of open capillaries in the tissue. Results in increased o2 delivery and increased waste. Myogenic and metabolic factors work together: example: reactive hyperemia removal. An increase in tissue blood flow following a period of low perfusion due to a physical barricade.
