PSYC 2410 Lecture : Genetics and Pharmacology.docx
1 Aug 2013
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Deliberate genetic manipulation: gene knockout and gene knockin) Synthesis, storage in vesicles, break down in cytoplasm of any neurotransmitter that leaks from vesicle, exocytosis, inhibitory feedback via autoreceptors, activation of post-synaptic receptors, deactivation. Drugs can come in and change this at any of these steps: agonist: a drug that facilitates the effects of a particular neurotransmitter, antagonist: a drug that inhibits the effects of a neurotransmitter. Neuromodulators (do not bind to same site, bind to allosteric site in order to modulate conformation of transmembrane protein: can help or keep it closed. Used in chemical lesioning of a part of the brain (cytotoxicity: too much glutamate and cells can over fire and die. Produced in many neurons throughout the brain. Four receptors: 1- nmda receptor, 2- ampa receptor, 3- kainate receptor. Ionotropic (na+/ca2+) receptors: 4- metabotropic glutamate receptor (mglur - 8 subtypes)
