PATH 3610 Lecture Notes - Lecture 2: Disseminated Intravascular Coagulation, Thrombus, Heart Failure

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vince

Document Summary

Unit 2: changes in blood flow and body fluids. Oncotic pressure" thus refers to the pressure generated by this act of osmosis. In most normal tissues, the tissue hydrostatic and oncotic pressures are near zero, and as such contribute little to fluid exchange. In the normal capillary, at the arteriolar end of the capillary bed vascular hydrostatic pressure (pushing fluid out of vessels) is higher than the vascular oncotic pressure (drawing fluid into vessels). This drives fluid back into blood vessels, carrying away the metabolic waste byproducts of the tissues (carbon dioxide, etc: normally, tissue hydrostatic and colloid oncotic pressures are near zero, and do not really affect this fluid exchange. Two important causes of localized edema are: venous obstruction lymphatic obstruction: will lead to elevated tissue colloid osmotic pressure, which will favour fluid remaining in the tissue spaces. If this edema persists, the edematous tissue may undergo fibrosis causing the affected area to become firm and thickened.