PATH 3610 Lecture 1: Unit 2 Notes

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vince

Document Summary

Before you can understand abnormalities in blood flow and body fluid balance, it is important to have some understanding of normal fluid exchange in the body. 75-78 in your textbook, and to view fig 3-2 on p. 77, which examines the factors affecting fluid transit across capillary walls. 1: hyperemic tissues are redder than normal because of engorgement with oxygenated blood, congestion is a passive process resulting from impaired outflow of venous blood from a tissue. In chronic pulmonary congestion, the septa become thickened and fibrotic, and the alveolar spaces contain numerous macrophages laden with hemosiderin ( heart failure cells ) derived from phagocytosed red cells. In acute hepatic congestion, the central vein and sinusoids are distended with blood, and there may be central hepatocyte dropout due to necrosis. The periportal hepatocytes, better oxygenated because of their proximity to hepatic arterioles, experience less severe hypoxia and may develop only reversible fatty change.