NUTR 3330 Lecture 11: NUTR3330 Lecture 11
Document Summary
Vitamin k-dependent blood coagulation proteins: synthesized in the liver, have multiple gla residues, allows for binding of multiple calcium ions, chelates calcium and forms bridges on membrane at injury site, lead to ___ formation, allow clot to form. Vitamin k and bone: specific proteins involved in bone health need vitamin k for their synthesis, 1. Bone gla protein (bgp: vitamin k dependent protein, synthesized by osteoblasts, contains 3 gla residues, very abundant in bone, especially growing bone, gla residues facilitate calcium binding, bone mineralization, 2. Vitamin k deficiency: uncommon in healthy adults, several factors prevent deficiency, widespread distribution of vitamin k in foods, vitamin k cycle which conserves the vitamin, microbiological flora of the gut (recall form of vitamin k: _menaquinone) Vitamin k deficiency symptoms: hemorrhages, prolonged clotting time, susceptible groups, newborns exclusively breast fed, breast milk is a poor source of vitamin k, lactating moms recommended to supplement with vitamin k, extended antibiotic use.
