BIOL 1090 Lecture Notes - Lecture 2: Membrane Fluidity, Lipid Bilayer, Cell Membrane
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23 Mar 2017
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A separate section or part of something. An area in which something can be considered in isolation from other things. Formed by the boundary and the contents. Compartmentalizes: divides a whole into separate parts or sections. Sequesters: keeps contents from mixing with others. The biological membranes contain a hydrated lipid bilayer = phospolipid bilayer. Amphipathic: having both hydrophobic (non-polar) and hydrophilic (polar) regions. Fluidity is an important feature of biological membranes. Nature of lipids in membrane: unsaturated lipids increase fluidity, saturated lipids reduce fluidity. Temperature: warming increases fluidity = liquid crystal, cooling decreases fluidity = crystalline gel. A balance between ordered (rigid) and disordered structure allows: Dynamic interactions between membrane components (ex: proteins can come together reversibly) If added to a liquid crystal membrane, fluidity will decrease. If added to a crystalline gel membrane, fluidity will increase. Fluid-mosaic model (singer/nicholson, 1972: bilayer of amphipathic lipids, proteins: integral (transmembrane), peripheral, lipid-anchored.
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