BPK 458 Lecture Notes - Lecture 1: Relative Risk Reduction, Genetic Linkage, Proteomics
24 Sep 2016
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Document Summary
Atherosclerosis is the accumulation of lipid within the wall of arterial blood vessels which causes narrowing and restriction of blood flow. These lipid accumulations, which occur in the intima are call atheroma"s. Atheroma"s develop on vessel walls and protrude into and even obstruct the vascular lumen. The most feared consequence of atherosclerosis is tissue ischemia and infarction, most often in the form of angina, myocardial infarction and stroke. Major arteries: largest arteries that supply blood to organs. Arteries: smaller arteries that branch off major arteries. Arterioles: even smaller arteries that branch off from arteries and carry blood to capillaries. Capillaries: smallest arteries that connect arterioles with venules and the location of transfer of gases and nutrients to body tissue. Lesions progress from isolated foam cells to fatty streaks to atheroma"s to fiberatheroma"s to complicated lesions. Begin as numerous flat yellow spots of diameter <1mm. Less t lymphocytes and extracellular lipid than plaques. All children over 10 have fatty streaks.
