BPK 458 Lecture 8: BPK 458 Week 11 Unit 8
21 Aug 2016
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Document Summary
Hydrophilic exterior contains phospholipids, cholesterol and apolipoproteins. Hydrophobic interior contains cholesterol esters and triglycerides. Lipoproteins can be separated by their charge by electrophoresis or by the density by ultracentrifugation or studied by nmr spectroscopy. The dietary fat is transported first in the lymph than into blood via chlyomicrons which are metabolized by lipoprotein lipase (hydrolyzed into free fatty acid and glycerol). The released fatty acids can either be used by working muscles for energy r stored in adipose tissue. The remaining small particles (chylomicron remnants) are taken up by the liver"s chylomicron from fat adipose tissue or from alcohol. It combines this fat with apolipoproteins and exports it in the form of mostly vldl. Vldl undergoes the same change on the periphery as chylomicrons and is transformed into intermediate and finally low density lipoproteins. Ldl serves as a source of cholesterol for extrahepatic tissues primarily tissues producing steroid hormones, such as adrenals, testes or ovaries.
