BISC 101 Lecture Notes - Lecture 2: Semiconservative Replication, Nitrogenous Base, Telomerase

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Cell cycle: cell growth (interphase) -> division of nucleus/geneic material (mitosis) -> division of cytoplasm (cytokinesis) Dna is replicated --> mitosis creates same geneic daughter cell, meiosis creates diferent daughter cells with half the geneic material. Mitosis = all geneic material/meiosis = half geneic material (reproducion) Cell has molecular checkpoints and is ightly regulated. [interphase] g1 (irst gap), s (dna synthesis), g2 (second gap) growth of cell. Some cells leave cell cycle and enter g0 (non-dividing) such as muscle cells. Chromosome: one dna molecule + histone proteins wrapping = nucleosomes. Genome = muliple chromosomes (total dna of cell) Sister chromains are replicated before mitosis and condensed at the start of mitosis (sister chromains are held together @centromere and by cohesin proteins) Kinetochore microtubules are atached to kinetochores on sister chromains. Mitoic spindle: microtubule structure with associated proteins (polymerizaion during mitosis) During anaphase: cohesin molecules break down and sister chromains separate.

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