PHAR 340 Lecture Notes - Lecture 4: Cell Signaling, Cyclic Adenosine Monophosphate, Adipocyte
Document Summary
Outside of cell, few can get across membrane. Signal reception amplification transduction response. Depends on receptor, could use enzymes or act directly. Turns signal from a few agonists into massive increase in second messengers. Trivial event at membrane, amplify to dampen unimportant information. If only 1 signal, hard to differentiate b/w signal and noise. Agents act on one cell but several agents can activate the same pathway via different cells. No, binding is trivial, talk for a short time to turn on enzyme, now info can be. Through receptors to determine if they should let things through e. g. in vessel, let wbcs out to infection. Help cell know where they are e. g. stem cells develop based on environment, will fail if they"re not where they"re supposed to be e. g. heart has different ec proteins than liver. Make a pocket for drug to fit into. Stimulate enzymes that generate second messengers (camp, ip3)