KINE 3012 Lecture Notes - Lecture 1: Endosome, Conformational Change, Lysosome
Document Summary
Adaptation/desensitization: prolonged exposure to a stimulus decreases the cells" response to that level of stimulus. Want to stop responding to a signal even when it is present. There is a negative feedback short delay. G-protein coupled receptors mediate most responses to signals fro the external world, as well as signals from other cells, including hormones, neurotransmitters, and local mediators. 800 gpcrs are in the human genome. Half of all known drugs work through these receptors or their pathways. Considered serpentine receptors because they snake back and forth along the membrane. Trimeric gtp-binding proteins (g proteins) couples the. Alpha and gamma subunits have membrane-bound fatty acids. When the signal molecule binds to the gpcr, gtp binds to the. In the inactive state, the alpha subunit has gdp bound alpha subunit of the g-protein, and it separates: alpha and gamma are activated and can regulate target proteins.