PHAR 100 Lecture Notes - Lecture 20: Cholesteryl Ester, Hyperlipidemia, Bile Acid

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emeraldwalrus65

12 Nov 2016

School

Queen's University

Department

Pharmacology and Toxicology

Course

PHAR 100

Professor

Bill Racz

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Document Summary

Atherosclerosis build up of fatty plaques (atheros) on inside of vessel wall. Main plasma lipids: cholesterol, cholesterol esters, triglycerides and phospholipids. Cholesterol: white, waxy material composed of steroid hormones, vitamin d, bile salts and cell membranes. Important in formation of glucocorticoids and sex hormones, vitamin d. Composed of 3 fatty acids and a glycerol molecule. Lipoproteins: composed of lipids and proteins (apolipoproteins) keep lipids soluble and move them in and out of cells. Chylomicrons: largest lipoprotein, carries exogenous tg, formed in the intestine. Very low density lipoproteins (vldl): formed in the liver, carry endogenous tg. Intermediate density lipoproteins (idlp): intermediary between ldl and hdl. Low density lipoproteins (ldl): derived from idl. Carry cholesterol to tissues including arteries- main cause of atherosclerosis. High density lipoproteins (hdl): good lipoproteins, carry cholesterol away from the arteries to the liver. Or secondary acquired with other metabolic disease ie) hypothyroidism. Treatment: diet control, elimination of aggravating factors and antihyperlipidemic drugs.

Related Questions

uestions 7. In the colorimetric determination of cholesterol the enzyme cholesterol oxidase, the agent that oxidi the colorless organic compound 4-aminoantipyrine a pink complex is a. Hydrogen peroxide bÂ·Cholest-4-ene-3-one . Which of the following methods for lipoprotein elec- trophoresis depends on charge and molecular size? b. Paper c. Cellulose acetate d. Agarose d. Phenol 2. Which of the following statements concerning chylomi- crons is FALSE? a. The major lipid transported by this lipoprotein is 8. Which lipoprotein is the major carrier of cholesterol to peripheral tissue? a. LDL b. Chylomicrons c. VLDL d. HDL cholesterol. b. This lipoprotein is produced in the intestinal c. The primary function is to carry dietary (exog d. It remains at the origin (point of application) dur- mucosa enous) lipids to the liver. ing lipoprotein electrophoresis. 9. True or false? Increased levels of apo A-I are associ- ated with increased risk of CAD 3. The lipoprotein that contains the greatest amount of protein is called a. HDL 10. A patient is admitted to the hospital with intense chest pains. The patient's primary care physician requests the emergency department doctor to orde several tests, including a lipid profile with chol fractionation.Given the patient's results below, what would be the LDL-C for this patient c. VLDL d. LDL 4. True or False? Pre-beta (VLDL)-lipoproteins migrate Total cholesterol- 400 mg/dL; triglycerides further toward the anode on polyacrylamide gel than HDLC - 100 mg/di LP electrophoresis, pending they do on cellulose acetate or agarose a. 240 mg/dL b. 160 mg/dL c. 200 mg/dL d. 300 mg/dL 5. Several enzymatic triglyceride methods measure the production or consumption of a. NADH b. Fatty acids c. Glycerol d. Diacetyl lutidine 11. A patient is admitted to the hospital wit chest pains. The patient's primry requests the emergency 6. The most likely cause for serum/plasma to appear several tests, including a lipid protile fractionation. Given the patient's resu below, what would be this patient s a "milky" is the presence of LDL-Cstatus 3u b. VLDL c. LDL d. HDL Total cholesterol 400 mg/dL; HDL-C = 100 mg/dL; LP electrop a. High b. Optimal c. Desirable d. Borderline

PHAR 100 Lecture Notes - Lecture 20: Cholesteryl Ester, Hyperlipidemia, Bile Acid

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