HTHSCI 1LL3 Lecture Notes - Lecture 5: Amide, Transmembrane Protein, Scleroprotein

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 1LL3
• Professor: Dr. Terry McCurdy

Document Summary

*quiz 3: biologic functional groups, amino acids & protein structure and function. Note: hydrogen bonding is important for holding proteins together: hydrogen bonding is when two electronegative (or electropositive) atoms share a hydrogen. Levels of structure: primary= what the dna instructs (amino acid order, secondary= alpha helices and beta sheets, mini folding structures, tertiary= 3-d folding structures, maintained mostly by non-covalent bonds, quaternary= only when there is multiple sub-units, e. g. hemoglobin. 01/24/17: backbone is always the n and c atoms bonding together, carbonyl and amino groups. Tertiary structure: alpha-helices and beta-sheets combine with irregular elements like loops and turns to make up the tertiary structure, primary structure defines which secondary structure will be adopted and which tertiary structure conformation every molecule will have. Quaternary structure: proteins made up of more than one sub-unit, sub-units may be the same or different, dimers, trimmers, etc, homodimer or heterodimer, e. g. hemoglobin has two alpha sub-units and two beta sub-units.