PHGY 311 Lecture Notes - Lecture 6: Autocrine Signalling, California State Route 14, Chelation
13 Dec 2012
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Release of vp is to increase water retention, do this by changing firing pattern into phasic activity, or else get a sig. low release of vp. Hyperpolarize the vp neuron, this moves away form ap threshold and can see if the epsps have the same phasic pattern. Turns out they don"t, thus this patterning mechanism is intrinsic to the vp neuron and it is not a synaptic property. Diff type of potentials resp. for phasic activity. The hap is meant to prevent a subsequent ap from happen. Dap role is to facilitate the triggering of a second ap-summates with subsequent epspand u get a burst of activitysee dap only when u get an ap (not present with only epsp) Partial overlap in time between all threebalance is what determines the outcome. See rise in intracellular ca after the spike. Experimenters took bapta which is a chelating material to absorb the intracellular ca.
