PHGY 209 Lecture Notes - Lecture 23: Pathogen-Associated Molecular Pattern, Vaccinia, Smallpox
30 Oct 2016
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Vacination: vaccinia immunization, last case of small pox. Last person to contract small pox in the wild in 1977. Two additional cases acquired accidentally during lab in 1978. Five different kinds of terms used for antigen: immunogen. Must be seen as threatful: hapten (+ carrier = immunogen) Carried by a serum protein because it needs to be bigger (>10. Hay fever during spring summer and fall: tolerogen. One in a 10 billion would accept a kidney transplant unless u have an identical twin. Happens first in eutero and then throughout life: ligand. Ligan can bind to something else (antibody) The coverings of the body: skin and mucus membranes, the innate immune response, the adaptive (acquired ) immune response. Skin and mucus membranes have unpleasant living conditions for microorganisms: epidermis, mucus, ph, enzymes. First cells that come involved with the immune response in bacteria and humans is the fixed tissue macrophages: takes up bacteria and eats them, it is phagocytic.
