PHAR 303 Lecture Notes - Lecture 4: Toxicokinetics, Toxicant, Chloramphenicol

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 303
• Professor: Bernard Robaire

Document Summary

Toxicokinetics: the modeling and mathematical description of the time course of disposition of toxicants. Routes of absorption, excretion of toxicants distribution, and. Usually, it"s not intravenous, unless it"s a venomous snake bite. Focus is usually on what is eaten, inhaled, or absorbed dermally. We are worried about the gi tract and the lungs as delivery mechanisms as well as what gets through the skin. Toxicants get into a central compartment where it will be delivered to the rest of the body. Whether a toxin is absorbed through the skin, lung, or gi tract, it has to get through a membrane. If a toxicant is fat-soluble it will get across the membrane more easily. They can also get through ion channels or be transported by proteins. Water-soluble drugs can go through the membrane by passive diffusion through aqueous channels. Sometimes there are carriers that recognize exogenous compounds and will carry them across via active transport or facilitated diffusion.