ANAT 322 Lecture Notes - Lecture 16: Phthalate, Deet, Paraben
3 Sep 2016
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Document Summary
Chemicals & endocrine disruptors very important for regulating physiology. Downstream have high incidence of intersex fish (e. g. testis w/oocytes) Preferentially mate w/males w/compromised immune function affect future generations! Given to women to prevent miscarriage offspring have higher risk of cancer. Genestein: can reverse some effects of bpa (also estrogen-like compound); has effects itself. Can go through placenta, into fetus disrupt development, deleterious effects. Can act at very low levels, are everywhere in environment, many compounds & systems, fetal exposure impacts adult health. Act through receptor to stimulate response (same or diff from endogenonous hormone) Can have direct interaction w/nuclear receptor e. g. bpa binds both era & b. Inhibit activity of receptor by activating inhibiting elements. Change availability of hormone to its receptors & stimulate degradation of hormone. But edc not monotonic (not linear): low-dose effects very diff from high-dose. Critical periods of exposure (pregnancy, perinatal, puberty, adult) Effects: sexually-dimorphic, reproduction, neuro development (also affecting sex)
