91401 Lecture Notes - Lecture 2: Innate Immune System, Interleukin 10, Cytokine
Document Summary
Innate immunity 3: cytokines - proteins, act as signalling molecules for the immune system, secreted by cells generally of low molecular weight, bind to receptors on immune cells that help determine the nature of an immune response. Control expansion and differentiation of t cells and b cells. Properties of cytokines: produced by cells of innate and adaptive immunity, activate and suppress inflammatory/immune responses, pleiotropic, redundant, synergistic, antagonist. Pleiotropism multiple effects ; cytokines can have different effects on immune cells: e. g. Il-10: suppress t cells but can enhance b cell activation. Redundancy some cytokines play redundant roles (a cytokine can have overlapping roles with another cytokine) Synergy two or more cytokines acting on an immune cell to enhance a response response is greater than the sum of their individual effects. Antagonism one cytokine suppresses the activity of another cytokine (counter one another"s activity) Effects of cytokines are controlled secretion by cells is brief. May be stored in a pro-form (il-1 )
