PHY3181 Lecture 8: Reproductive brain 2
10 Feb 2019
School
Department
Course
Professor
Document Summary
Gating system - regulated by convergent pathways. Gnrh neurons do not typically express the relevant receptors for direct action at. Info regarding steroids/nutrition/stress are processed in other brain regions and then relayed to gnrh neurons: prevents information overload at a single neuron, allows them to act in concert. Gnrh neurons do not contain er , pr, ar. Function of er unknown (not involved in steroid feedback) Cells that relay steroid feedback to gnrh = kisspeptin + gonadotropin inhibitory hormone (gnih) Kiss1 (gene) kiss1 (mrna) kisspeptin (protein) gpr54 (receptor) Feedback system in the arcuate nucleus (arc) and preoptic area (poa) - both are different types: all arcuate nucleus kisspeptin cells have er , 50% of preoptic kisspeptin cells have er . Any mutations in the kisspeptin system causes infertility. Mutations in the kiss1 gene or gpr54 receptor don"t enter puberty. Only kndy cells do not directly contact gnrh neurons. Kisspeptin fibres from preoptic nerve directly contact gnrh neurons.
